I've had 'roids and still managed full anal penetration. You just need to be more careful and slow, take time with it, start with one finger and lots of lube and work up. The anus still stretches and accomodates it can just be a little more painful afterwards, however on a personal note I like that, it proves I have been used and keeps a welcome reminder. I do use a good cream afterwards to help a little witht the soreness.